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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Nutrients, Phytochemicals, and In Vitro Antioxidant and Antimicrobial Activities of Lulo (Solanum quitoense Lam.) Fruit Pulp, Peel, and Seeds

Lulo or naranjilla (Solanum quitoense Lam.) is an Andean fruit with a sour and refreshing flavor, widely used in the preparation of juices and sweets. Despite its potential for international markets, it remains largely unknown outside its native regions, and most existing studies have focused on the whole fruit or its juice. This study investigated the nu-tritional and phenolic profiles of the peel, pulp, and seeds of S. quitoense using...

Impact of ex vivo cell culturing on ABC transporters’ expression and drug sensitivity in patient-derived non-small cell lung cancer models

Objectives Non-small cell lung cancer (NSCLC) treatment is complicated by interactions between cancer and stromal cells, as well as drug resistance linked to ATP-binding cassette (ABC) transporters. While previous studies have explored ABC transporter expression and drug responses in patient-derived NSCLC cultures, the impact of culture duration remains unclear. This study compares short-term and long-term primary culture models to assess how extended...

Physiological and Oxidative Stress in General and Spinal Anesthesia for Elective Cesarean Section in Women: Is There Any Difference?

This study evaluates the influence of general anesthesia (GA) and spinal anesthesia (SA) on physiological and oxidative stress in parturients undergoing elective cesarean section, one of the most frequently performed surgical procedures worldwide. A total of 101 pregnant women were included, categorized into GA (n = 51) and SA (n = 50) groups. Blood samples were collected at three time points: one hour before surgery (Measurement 1), at umbilical cord clamping (Measurement 2)...

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