#173041 Molecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stress

The specific area of research represents investigation of regulation of oxidant-induced changes of aerobic organisms and we develop three various areas of investigation: 1) biomonitoring of aquatic organisms, 2) toxicology and 3) biomarkers and pathophysiological states.

1) Biomonitoring of aquatic organisms. Molecular and physiological biomonitoring based on the antioxidant defense enzyme activities as biochemical biomarkers: superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and the concentrations of vitamin E, vitamin C, glutathione.

2) Toxicology. Prooxidative effects of cadmium and cisplatin in acute and chronic treatment and protective role of antioxidants on alteration of oxidative stress biochemical biomarkers in the blood and tissues of mail Wistar albino rats will be investigated.

3) Biomarkers and pathophysiological states. The study of estradiol and its role inpreeclampsia, the assessment of oxidative damage and antioxidative capacity of healthy tissues in response to therapeutic doses of radiation in the treatment of breast cancer and the pathogenesis of gastrointestinal disorders will be investigated.

Results of the project would be of great significance in providing the answers to three thematic units:

1) application of molecular physiological biomonitoring on aquatic organisms as a model system for monitoring of the effects of single pollutants as biomarkers of oxidative stress,

2) investigation of the effects of toxicants on AOS and the possibility of the application of antioxidants to decrease or eliminate toxic effects and

3) measurement of an adequate biochemical biomarkers of oxidative stress and assessment of therapy effectiveness and choice of appropiate treatment in the early stages of disease.

Project team:

Dr. Slađan Pavlović, project leader
Dr. Slavica Borković Mitić
Dr. Tijana Radovanović
Dr. Branka Gavrilović
Dr. Svetlana Despotović
Dr. Jelena Gavrić
Dr. Marko Prokić
Tamara Petrović
Vinča Institute of Nuclear Sciences, University of Belgrade:
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Faculty of Science, University of Kragujevac:
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Medical Faculty, University of Kragujevac:
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National University in Novi Pazar:
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