Neurobiology of sleep in aging and disease - electroencephalographic markers and modeling in the estimation of disorder #173022

  1. Saponjic J, Cvorovic J, Radulovacki M, Carley DW. Serotonin and noradrenaline modulate respiratory pattern disturbance evoked by glutamate injection into the pedunculopontine tegmentum of anesthetized rats. Sleep. 2005;28:560-70.
  2. Saponjic J, Radulovacki M, Carley DW. Modulation of respiratory pattern and upper airway muscle activity by the pedunculopontine tegmentum: Role of NMDA receptors. Sleep Breath. 2006;10:195-202.
  3. Saponjic J, Radulovacki M, Carley DW. Monoaminergic system lesions increase post-sigh respiratory pattern disturbance during sleep in rats. Physiol Behav. 2007;90:1-10.
  4. Bojic T, SaponjicJ, Radulovacki M, Carley DW, Kalauzi A. Monotone signal segments analysis as a novel method of breath detection and breath-to-breath interval analysis in rat. Respir Physiol Neurobiol. 2008;161:273-80.
  5. Bjelobaba I, Saponjic J. High volume microinfusion suppresses local astrocyte response within nucleus basalis of rat. Arch Ital Biol. 2013;151:24-32.
  6. Saponjic J, Petrovic J, Kalauzi A, Ciric J, Lazic K, Radulovacki M, Carley DW. Sleep-state related EEG amplitude distribution in the rat model of cortical cholinergic innervation disorder. Sleep Biol Rhythms. 2013;11(2):105-15.
  7. Petrovic J, Ciric J, Lazic K, Kalauzi A, Saponjic J. Lesion of the pedunculopontine tegmental nucleus in rat augments cortical activation and disturbs sleep/wake state transitions structure. Exp Neurol. 2013;247:562-71.
  8. Petrovic J, Lazic K, Ciric J, Kalauzi A, Saponjic J. Topography of the sleep/wake states related EEG microstructure and transitions structure differentiates the functionally distinct cholinergic innervation disorders in rat. Behav Brain Res. 2013;256:108-18.
  9. Petrovic J, Lazic K, Kalauzi A, Saponjic J. REM sleep diversity following the pedunculopontine tegmental nucleus lesion in rat. Behav Brain Res. 2014;271:258–68.
  10. Bataveljic D, Petrovic J, Lazic K, Saponjic J, Andjus P. Glial response in the rat models of functionally distinct cholinergic neuronal denervations. J Neurosci Res. 2015;93(2):244-52.
  11. Ciric J, Lazic K, Petrovic J, Kalauzi A, Saponjic J. Aging induced cortical drive alterations during sleep in rats. Mech Ageing Dev. 2015;146-148C:12–22.
  12. Lazic K, Petrovic J, Ciric J, Kalauzi a., Saponjic J. Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson’s disease neuropathology. Neuroscience. 2015;304:1–13.

Brain plasticity in aging: effect of dietary restriction and anesthesia #173056

  1. Tesic V, Perovic M, Lazic D, Kojic S, Smiljanic K, Ruzdijic S, Rakic L, Kanazir S. Long-term intermittent feeding restores impaired GR signaling in the hippocampus of aged rat. J Steroid Biochem Mol Biol. 2015;149C:43-52.
  2. Smiljanic K, Pesic V, Mladenovic Djordjevic A, Pavkovic Z, Brkic M, Ruzdijic S, Kanazir S. Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats. Biogerontology. 2015;16:71-83.
  3. Smiljanic K, Vanmierlo T, Mladenovic-Djordjevic A, Perovic M, Ivkovic S, Luetjohann D, Kanazir S. Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. AGE. 2014;36(3):1303-14.
  4. Milanović D, Pešić V, Popić J, Tanić N, Kanazir S, Jevtović-Todorović V, Ruždijić S. Propofol anesthesia induces proapoptotic tumor necrosis factor-α and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain. J Neurosci Res. 2014;92(10):1362-73.
  5. Mladenovic Djordjevic A, Perovic M, Smiljanic K, Todorovic S, Tesic V, Ruzdijic S, Kanazir S. The effects of dietary restriction and aging on amyloid precursor protein and presenilin-1 mRNA and protein expression in rat brain. Neuroreport. 2014;25(6):398-403.
  6. Perovic M, Tesic V, Mladenovic Djordjevic A, Smiljanic K, Loncarevic-Vasiljkovic N, Ruzdijic S, Kanazir S. BDNF transcripts, proBDNF and proNGF, in the cortex and hippocampus throughout the life span of the rat. AGE. 2013;35(6):2057-70.
  7. Smiljanic K, Vanmierlo T, Mladenovic Djordjevic A, Perovic M, Loncarevic-Vasiljkovic N, Tesic V, Rakic Lj, Ruzdijic S, Lutjohann D, Kanazir S. Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver. Lipids. 2013;48(11):1069-77.
  8. Popic J, Pesic V, Milanovic D, Todorovic S, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo. PLoS One. 2012;7(4):e34396.
  9. Loncarevic-Vasiljkovic N, Pesic V, Todorovic S, Popic J, Smiljanic K, Milanovic D, Ruzdijic S, Kanazir S. Caloric restriction suppresses microglial activation and prevents neuroapoptosis following cortical injury in rats. PLoS One. 2012;7(5):e37215.
  10. Milanovic D, Popic J, Pesic V, Loncarevic-Vasiljkovic N, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. Regional and temporal profiles of calpain and caspase-3 activities in postnatal rat brain following repeated propofol administration. Dev Neurosci. 2010;32(4):288-301.
  11. Pesić V, Milanović D, Tanić N, Popić J, Kanazir S, Jevtović-Todorović V, Ruzdijić S. Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia. Int J Dev Neurosci. 2009;27(3):279-87

Cellular and molecular basis of neuroinflammation: potential targets for translational medicine and therapy #41014

  1. Božić I, Savić D, Laketa D, Bjelobaba I, Milenković I, Peković S, Nedeljković N, Lavrnja I. Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia. PLoS One. 2015;10(2):e0118372.
  2. Lavrnja I, Trifunovic S, Ajdzanovic V, Pekovic S, Bjelobaba I, Stojiljkovic M, Milosevic V. Sensorimotor cortex ablation induces time-dependent response of ACTH cells in adult rats: behavioral, immunohistomorphometric and hormonal study. Physiol Behav. 2014;125:30–7.
  3. Lavrnja I, Ajdzanovic V, Trifunovic S, Savic D, Milosevic V, Stojiljkovic M, Pekovic S. Cortical ablation induces time-dependent changes in rat pituitary somatotrophs and upregulates growth hormone receptor expression in the injured cortex. J Neurosci Res. 2014;92(10):1338–49.
  4. Lavrnja I, Laketa D, Savic D, Bozic I, Bjelobaba I, Pekovic S, Nedeljkovic N. Expression of a second ecto-5'-nucleotidase variant besides the usual protein in symptomatic phase of experimental autoimmune encephalomyelitis. J Mol Neurosci. 2015;55(4):898–911.
  5. Savić D, Stojiljkovic M, Lavrnja I, Parabucki A, Bjelobaba I, Nedeljkovic N, Herdegen T, Pekovic S. Ribavirin shows immunomodulatory effects on activated microglia. Immunopharmacol Immunotoxicol. 2014;36(6):433–41.
  6. Brkic P, Stojiljkovic M, Jovanovic T, Dacic S, Lavrnja I, Savic D, Parabucki A, Bjelobaba I, Rakic L, Pekovic S. Hyperbaric oxygenation improves locomotor ability by enhancing neuroplastic responses after cortical ablation in rats. Brain Injury. 2012. p. 1273–84.
  7. Parabucki AB, Bozić ID, Bjelobaba IM, Lavrnja IC, Brkić PD, Jovanović TS, Savić DZ, Stojiljković MB, Peković SM. Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats. Croat Med J. 2012;53(6):586–97.
  8. Lavrnja I, Savic D, Bjelobaba I, Dacic S, Bozic I, Parabucki A, Nedeljkovic N, Pekovic S, Rakic L, Stojiljkovic M. The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis. Journal of Pharmacological Sciences. 2012. p. 221–32.
  9. Bjelobaba I, Lavrnja I, Parabucki A, Stojkov D, Stojiljkovic M, Pekovic S, Nedeljkovic N. The cortical stab injury induces beading of fibers expressing ecto-nucleoside triphosphate diphosphohydrolase 3. Neuroscience. 2010;170:107-16.
  10. Laketa D, Bjelobaba I, Savic J, Lavrnja I, Stojiljkovic M, Rakic L, Nedeljkovic N. Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum. Mol Cell Biochem. 2010;339:99-106.
  11. Lavrnja I, Stojkov D, Bjelobaba I, Pekovic S, Dacic S, Nedeljkovic N, Mostarica-Stojkovic M, Stosic-Grujicic S, Rakic L, Stojiljkovic M. Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production. Int Immunopharmacol. 2008;8:1282-90.
  12. Stojkov D, Lavrnja I, Pekovic S, Dacic S, Bjelobaba I, Mostarica-Stojkovic M, Stosic-Grujicic S, Jovanovic S, Nedeljkovic N, Rakic L, Stojiljkovic M. Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: clinical and histopathological evaluation. J Neurol Sci. 2008;267:76-85
  13. Nedeljkovic N, Bjelobaba I, Subasic S, Lavrnja I, Pekovic S, Stojkov D, Vjestica A, Rakic L, Stojiljkovic M. Up-regulation of ectonucleotidase activity after cortical stab injury in rats. Cell Biol Int. 2006;306:541-6.
  14. Pekovic S, Subasic S, Nedeljkovic N, Bjelobaba I, Fillipovic R, Milenkovic I, Lavrnja I, Stojkov D, Jovanovic S, Rakic Lj, Stojiljkovic M. Molecular basis of brain injury and repair. In: Ruzdijic S, Rakic Lj, editors. Neurobiological studies – From genes to behavior. Keral: Research Signpost; 2006.p.143-65.
  15. Peković S, Filipović R, Subasić S, Lavrnja I, Stojkov D, Nedeljković N, Rakić L, Stojiljković M. Downregulation of glial scarring after brain injury: the effect of purine nucleoside analogue ribavirin. Ann NY Acad Sci. 2005,1048:296-310

Identification of Predictive Molecular Markers for Cancer Progression, Response to Therapy and Disease Outcome#41031

  1. Stojsic J, Stankovic T, Stojkovic S, Milinkovic V, Dinic J, Milosevic Z, Milovanovic Z, Tanic N, Bankovic J. Prolonged survival after neoadjuvant chemotherapy related with specific molecular alterations in the patients with nonsmall-cell lung carcinoma. Exp Mol Pathol. 2014;98(1):27-32.
  2. Dinić J, Novaković M, Podolski-Renić A, Stojković S, Mandić B, Tešević V, Vajs V, Isaković A, Pešić M. Antioxidative activity of diarylheptanoids from the bark of black alder (Alnus glutinosa) and their interaction with anticancer drugs. Planta Med. 2014;80(13):1088-96.
  3. Milosevic Z, Pesic M, Stankovic T, Dinic J, Milovanovic Z, Stojsic J, Dzodic R, Tanic N, Bankovic J. Targeting RAS/MAPK/ERK and PI3K/AKT/mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma. Transl Res. 2014;164(5):411-23.
  4. Mori M, Vignaroli G, Cau Y, Dinić J, Hill R, Rossi M, Colecchia D, Pešić M, Link W, Chiariello M, Ottmann C, Botta M. Discovery of 14-3-3 protein-protein interaction inhibitors that sensitize multidrug-resistant cancer cells to doxorubicin and the Akt inhibitor GSK690693. ChemMedChem. 2014;9(5):973-83.
  5. Stankovic T, Milinkovic V, Bankovic J, Dinic J, Tanic N, Dramicanin T, Tanic N. Comparative analyses of individual and multiple alterations of p53, PTEN and p16 in non-small cell lung carcinoma, glioma and breast carcinoma samples. Biomed Pharmacother. 2014;68(5):521-6.
  6. Liu Q, Manzano D, Tanić N, Pesic M, Bankovic J, Pateraki I, Ricard L, Ferrer A, de Vos R, van de Krol S, Bouwmeester H. Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway. Metab Eng. 2014;23:145-53.
  7. Novaković M, Pešić M, Trifunović S, Vučković I, Todorović N, Podolski-Renić A, Dinić J, Stojković S, Tešević V, Vajs V, Milosavljević S. Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. Phytochemistry. 2014;97:46-54.
  8. Milinkovic V, Bankovic J, Rakic M, Stankovic T, Skender-Gazibara M, Ruzdijic S, Tanic N. Identification of novel genetic alterations in samples of malignant glioma patients. PLoS One. 2013;8(12):e82108.
  9. Podolski-Renic A, Jadranin M, Stankovic T, Bankovic J, Stojkovic S, Chiourea M, Aljancic I, Vajs V, Tesevic V, Ruzdijic S, Gagos S, Tanic N, Pesic M. Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. Cancer Chem Pharmacol. 2013;72(3):683-97.
  10. Banković J, Andrä J, Todorović N, Podolski-Renić A, Milošević Z, Miljković D, Krause J, Ruždijić S, Tanić N, Pešić M. The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2: the unique way of multi-drug resistance modulation. Exp Cell Res. 2013;319(7):1013-27.
  11. Dačević M, Isaković A, Podolski-Renić A, Isaković AM, Stanković T, Milošević Z, Rakić Lj, Ruždijić S, Pešić M. Purine nucleoside analog - sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines. PLoS One. 2013;8(1):e54044.
  12. Jadranin M, Pešić M, Aljančić IS, Milosavljević SM, Todorović NM, Podolski-Renić A, Banković J, Tanić N, Marković I, Vajs VE, Tešević VV. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. Phytochemistry. 2013;86:208-17.


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