#41009 Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of Metabolic Syndrome – molecular mechanisms and clinical implications

The Laboratory of Professor Matić gathers a group of young scientists committed to the study of neuroendocrine and dietary aspects of the development of Metabolic Syndrome, which is one of the leading health problems worldwide. Our scientific endeavors are primarily focused on the molecular mechanisms of glucocorticoid hormones actions in the development of Metabolic Syndrome, since these hormones are important regulators of energy homeostasis, metabolic inflammation, as well as of insulin and leptin signalling pathways. In the next three years the role of stress and fructose diet in the development of Metabolic Syndrome will be elucidated through collaboration with Professor Luc Tappy's group from Switzerland as a part of the SCOPES Joint Research Project entitled: Interactions between stress and dietary fructose in the development of the metabolic syndrome: role of glucocorticoids.

A part of our scientific research is focused on the role of glucocorticoids in the pathogenesis of stress-related diseases, among which are Polycystic Ovary Syndrome (PCOS) characterized by both reproductive and metabolic disturbances, and Posttraumatic Stress Disorder investigated as a part of international project Psychobiology of Posttraumatic Stress Disorder supported by The European Commission within the frames of Framework Six Programme (FP6).

We conduct our current research on animal models of Metabolic Syndrome andPCOS using experimenatal techniques ranging from biochemical and endocrinological analyses to methods such as ELISA, Western blot and qPCR, as well as proteomics and behavioral testing.

Two research groups participating in the implementation of the project beside Prof. Matić's grour are the group of Dr. Goran Korićanac at VINČA Institute and the group of Prof. Svetozar Damjanović from the Institute for Endocrinology, Diabetes and Metabolic Diseases. This collaboration is aimed at facilitating translation of the project results to clinical practice.

Project team:

Dr. Gordana Matić, team leader

Dr. Nataša Veličković

Dr. Ana Đorđević

Dr. Danijela Vojnović Milutinović

Dr. Ivana Elaković

Dr. Jelena Nestorov

Dr. Biljana Bursać

Dr. Ana Teofilović

Dr. Marina Nikolić

Sanja Kovačević

Ljupka Gligorovska

Bojana Mićić

 

Address

Bulevar despota Stefana 142
11108 Belgrade
Serbia

Contact

Telefon: +381 11 20 78 300
Fax: +381 11 27 61 433
Email: ibiss@ibiss.bg.ac.rs

futer excellent