Although cisplatin-based chemotherapeutic agents induce DNA damage, their cytotoxicity is achieved through a series of interactions with various intracellular structures. The effectiveness of these therapeutics in melanoma is limited by strong DNA repair mechanisms, and the project aims to create tetraaryl tin(IV) compounds packed in nanostructured silica particles. Based on preliminary data on the effectiveness of tin-based compounds and mesoporous silica nanoparticles, these are expected to exhibit superior properties compared to existing metal complex-based chemotherapeutics at both the intracellular and intercellular levels. With this approach, increased drug delivery to the target tissue and reduced systemic toxicity are expected.

Partner in Germany: University of Applied Sciences Merseburg

Coordinator for Serbia: Dr. Sanja Mijatovic, Department of Immunology IBISS

Team members from IBISS:
Dr. Danijela Maksimović-Ivanić, Department of Immunology
Ekatarina Mihajlović, Department of Immunology
Teodora Komazec, Department of Immunology

External advisors:
Prof. Dr. Goran Kaluderovic, Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg
Til J. Becker, Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg