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Institute for Biological Research "Siniša Stanković"
National Institute of the Republic of Serbia
University of Belgrade

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Natural-Origin Compounds as Future Precision Partners in Combination Cancer Therapy

Cancer multidrug resistance (MDR), particularly mediated by ATP-binding cassette (ABC) transporters, can link ABC transporters’ ATP-dependent efflux to Nrf2-driven antioxidant defence. This connection reduces the oxidative threshold in MDR cancer cells. Natural or nature-inspired compounds can target this vulnerability and induce collateral sensitivity (CS) by simultaneously modulating the redox balance and ABC transporters’ activity in MDR cancer cells. Moreover, natural-origin compounds can act on multiple targets by combining efflux inhibition, redox modulation...

NRF2 signalling in cancer-associated adipose tissue supports Warburg effect and early metabolic integration in breast cancer

Objective: Metabolic crosstalk between breast cancer cells and cancer-associated adipose tissue (CAAT), the major component of their tumour microenvironment (TME), is prerequisite for malignant phenotype. Nuclear factor erythroid 2-related factor 2 (NRF2) is a key factor in redox–metabolic interplay; however, its role in TME during breast tumourigenesis, particularly regarding the Warburg effect, remains unexplored. Methods: Using an orthotopic breast cancer model in wild-type (WT)...

Sustainable ex-situ cultivation of Trametes versicolor (L.) Lloyd using forest biomass: impacts on nutritional, chemical, and bioactive...

The controlled cultivation of Trametes versicolor (L.) Lloyd, a medicinal mushroom with proven health benefits, represents a sustainable strategy for the development of reproducible functional ingredients from lignocellulosic biomass. This study evaluated the nutritional, chemical, and bioactive profiles of fruiting bodies cultivated in a controlled environment (CEA) using forest biomass-derived substrates, compared to logs collected in the wild. Fruiting was achieved in 68% of the inoculated...

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