"Efekat elektromagnetnog polja (50 Hz, 0,25 mT) na komponente adaptivne vrednosti i morfometriju krila kod Drosophila subobscura Collin, 1936 (Insecta, Diptera)"
IBISS Library
3rd June 2016 at 13.00
Lecturer: Boris Šakić, Ph.D., Associate Professor, Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
Time: 30th May 2016, 14.00
Place: IBISS Library
"Metaboličke karakteristike sindroma policističnih jajnika u visceralnom masnom tkivu i leptinska rezistencija u hipotalamusu pacova tretiranog 5α-dihidrotestosteronom: uloga glukokortikoida"
IBISS Library
26th February 2016. at 15.00
"Antiinflamatorna i antioksidativna svojstva benfotiamina u aktiviranoj liniji mikroglijskih ćelija miša: uloga proinflamatornih signalnih puteva"
IBISS Library
1st March 2016 at 12.00
"Morfogeneza i regeneracija biljaka šalota (Allium ascalonicum L.) i vlašca (A. schoenoprasum L.) in vitro"
IBISS Library
7th June 2016 at 12.00
The aim of our research is to examine the effects of selected plant extracts, phytoestrogens (genistein, daidzein), steroid (estradiol, progesterone, testosterone, dexamethasone) and peptide hormones (somatostatin, calcitonin, ghrelin) on neuroendocrine and mineral homeostases in rats. Herbal and nature alternatives to hormone replacement therapy are intensively advertised for maintenance of hormone balance, prevention of cardiovascular problems, atherosclerosis and osteoporosis in both sexes. Assessments of effects of these substances on: (i) hypothalamo-pituitary -adrenal, -somatotropic, -thyroid and -gonadal axes; (ii) neuroendocrine C-cells, bones, parathyroid glands and kidneys; and (iii) cellular mechanics are important for evaluation of their health risks / benefits and potential use in treatment of cancer, cardiovascular and other diseases. The examinations are carried out in rats of different age (adult, middle and old age) and sex, with special emphasis on models of andropause and menopause. In vitro studies of cellular mechanics are performed using erythrocytes or prostate cancer cells. Glucocorticoids are used in human pregnancies at risk of preterm delivery because they reduce neonatal mortality and morbidity. However, this treatment enhances maturational processes and provokes permanent changes in physiological systems. Thus, short-term beneficial effects of prenatal glucocorticoids are, at the same time, the ones that increase the long-term risks of dysregulation of the metabolic function and endocrine axes, including stress response, growth and reproduction. Effects of prenatal glucocorticoid overexposure are examined in rats from their fetal period of life till adulthood.
The Laboratory of Professor Matić gathers a group of young scientists committed to the study of neuroendocrine and dietary aspects of the development of Metabolic Syndrome, which is one of the leading health problems worldwide. Our scientific endeavors are primarily focused on the molecular mechanisms of glucocorticoid hormones actions in the development of Metabolic Syndrome, since these hormones are important regulators of energy homeostasis, metabolic inflammation, as well as of insulin and leptin signalling pathways. In the next three years the role of stress and fructose diet in the development of Metabolic Syndrome will be elucidated through collaboration with Professor Luc Tappy's group from Switzerland as a part of the SCOPES Joint Research Project entitled: Interactions between stress and dietary fructose in the development of the metabolic syndrome: role of glucocorticoids.
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