Dr. Aleksandra Uskoković

Education:
• 2009: Ph.D. Faculty of Biology, University of Belgrade.
• 2002: M.Sc. Faculty of Chemistry (Biochemistry), University of Belgrade.
• 1997: B.Sc. (8.79/10), Faculty of Chemistry (Biochemistry), University of Belgrade.

Research title:
• 2020: Principal Research Fellow
• 2015: Senior Research Associate
• 2009: Research Associate
• 2002: Research Assistant
• 1997: Research Collaborator

Research interest:
• The protective mechanisms involved in the alleviation of diabetes (T1D and T2D) and diabetic complications; the basic mechanisms of DNA demethylation and regulation of TET enzyme activity that mediates active DNA demethylation by oxidizing 5-methylcytosine in DNA; to elucidate whether PARP inhibitors could affect cancer cells viability via induced TET activity and DNA demethylation, which could expand the application of PARP inhibition-based therapy beyond the treatment of BRCA-mutated ovarian and breast cancers (where PARP inhibitors were introduced due to the jointly effects with deficiency in homologous recombination which is synthetically lethal).

Participation in projects:
• National projects: The IBISS work program financed by the Ministry of Education, Technological Development and Innovation, Republic of Serbia (2020-), contract number 451-03-66/2024-03/200007; OI173020 of the Ministry of Research and Technological Development, Republic of Serbia (2011-2019); #143002B of the Ministry of Science and Environmental Protection, Republic of Serbia (2006-2010); #1722 of the Ministry of Science, Technology and Development, Republic of Serbia (2002-2006).
• International projects and collaborations: Bilateral project between Montenegro and Serbia (2016 - 2018); Project of 7th Framework Programme of European Commission „Managing the effects of multiple stressors on aquatic ecosystems under water scarcity“ No. 603629-ENV-2013-6.2.1-Globaqua (2014 - 2019); Participation and coordination of international cooperation with dr. Tomasz Jurkowski, Institute for Biochemistry, University of Stuttgart, Germany; COST actions: TD0905 (2010-2014), CA15219 (2016-2020), CA16119 (2017-2021).

Memberships in scientific societies:
• Serbian Society for Molecular Biology
• Serbian Biochemical Society – Member of the Publication Committee (since 2014)
• Serbian Proteomic Association (SePA)
• Serbian Biological Society