The main research topics of the Department of Immunology, Institute for Biological Research „Siniša Stanković" are organ-specific autoimmune and immunoinflammatory disorders (diabetes type 1 and type 2, and multiple sclerosis) and experimental immunooncology. Our research is predominantly conducted in animal models, but it also involves in vitro studies, as well as samples obtained from human subjects. Basic experimental models of Type 1 diabetes used are diabetes induced in inbred strains of mice and rats by multiple low doses of streptozotocin and spontaneous or accelerated diabetes in NOD mice, whereas type 2 diabetes is induced by high-fat diet. Experimental autoimmune encephalomyelitis (EAE) in Dark Agouti (DA) rats induced with central nervous system antigens is used as an experimental model of multiple sclerosis. Rats of Albino Oxford (AO) strain, resistant to the induction of diabetes and EAE are also involved in the studies. The basic aim of our studies is the discovery of molecular and cellular mechanisms responsible for the initiation, the development and the limitation of an autoimmune response in the diseases. Also, a possibility of pharmacological modulation of the autoimmune response is investigated. Regarding experimental immunooncology, the investigations are mainly focused on the efficacy of natural or synthetic agents in the treatment of transformed and/or immortalized cell lines in vitro, or animal tumor models in vivo. Beside evaluation of drugs' efficacy on the viability of tumor cells, different aspects of immune- and chemo-sensitization are explored.

• Role of gut microbiota in autoimmune diabetes and EAE
• Conversion of effector T cells into regulatory T cells
• Modulation of autoimmune diabetes and EAE by plant extracts
• The role of macrophage migration inhibitory factor in the development of type 1 and type 2 diabetes
• Modulation of autoimmune diabetes by the donor of carbon monoxide
• Effects of ethyl-pyruvate on neuroinflammation
• Tolerogenic dendritic cells and EAE
• The influence of natural or synthetic antiinflammatory and antimicrobial agents on the malignant cell viability and phenotype
• Evaluation of antitumor properties of newly designed and modified form of conventional chemotherapeutics
• Nanotechnology application in designing of novel therapeutic approaches
• Chemo- and immunosensitization of malignant cell


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