In different animal models (brain injury, multiple sclerosis: experimental autoimmune encephalomyelitis, cuprizone-induced demyelination) behavioral, cellular and molecular approaches (enzymatic assays, microdialysis combined with HPLC and bioluminescent detection, RT-PCR, immunoblot and immunohistochemistry, ELISA, confocal microscopy and whole cell patch clamp) are used. Besides in vivo neuroinflammatory processes are also studied in vitro in primary astrocytic and microglial cell culture, and glial cell lines. The main goal of the project is to identify, characterize and standardize potential early and sensitive biomarkers of neuroinflammation and neurodegeneration that can be used in clinical and laboratory practice for diagnosis and prognosis of patient outcome after damage to the CNS and for assessing the effectiveness of applied therapies. The project consists of 2 subprojects:
The role of purinergic signalling in acute and chronic neuroinflammation (principal investigator, prof. Nadežda Nedeljković).
Investigation of potential therapeutic approaches for sanitation of neuroinflammation and promotion of regeneration after
damage to the central nervous system (principal investigator, Sanja Peković, PhD).
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Other Collaborators:
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Faculty of Biology, University of Belgrade:
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School of Medicine, University of Belgrade:
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Vinča Institute of Nuclear Sciences, University of Belgrade:
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