The role of autophagy in therapy-induced tumor cell death will be analyzed using pharmacological inhibitors of autophagy or by blocking the expression of genes required for autophagosome formation. The relationship between autophagy and different types of cell death (apoptosis, necrosis), as well as molecular mechanisms responsible for autophagy-mediated regulation of cancer cell death (modulation of mitochondrial membrane potential, oxidative stress, signaling pathways and expression of genes that regulate cell cycle and death) will also be analyzed. Therapeutic potential of pharmacological modulation of autophagy will be investigated in vivo using experimental models of cancer or by analyzing autophagy induction in clinical samples of tumor tissue and its correlation with clinical and molecular prognostic markers.

Project team:

Dr. Ljubica Harharji-Trajković, project leader

Dr. Nevena Zogović

Dr. Gordana Tovilović Kovačević

Dr. Maja Misirkić Marjanović

Dr. Kristina Janjetović

Dr. Ljubica Vučićević

School of Medicine, University of Belgrade:

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