Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.

Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.

Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.

Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.

Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.

Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.

Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.

Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.

Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.

Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.

Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Epigenetics studies changes in gene expression that are not accompanied by changes in the sequence of DNA molecules, as well as their transmission and transgenerational maintenance. Researchers at the Institute study the mechanisms of stable maintenance of expression of certain genes (mechanisms of changes in the DNA methylation pattern), as well as the possibility of changing epigenetic marks for therapeutic purposes using CRISPR/Cas9 fused constructs. The target diseases researchers are focused on are diabetes and triple negative breast cancer.