Srđan Kesić graduated from the Faculty of Biology, University of Belgrade, in 2005 as the first and best student of his generation. At the same faculty, after completing doctoral studies in neurobiology, he defended PhD thesis in 2014, entitled "Application of Higuchi's fractal dimension and independent component method in the analysis of garden snail Br neuron bursting activity modulated by static magnetic field and ouabain". He also graduated from the Faculty of Philosophy, University of Belgrade, majoring in Philosophy in 2010. Dr. Srđan Kesić has been working at the Institute for Biological Research "Siniša Stanković" - Institute of National Importance for the Republic of Serbia, University of Belgrade, since 2005, where he has been involved in several research projects.
Dr. Kesić's research is focused on the study of the influence of various environmental factors and pharmacologically active substances on the central nervous system functioning, with a particular focus on the effects of prenatal and postnatal exposure to a low-frequency magnetic field on cognition and emotional behavior in peripuberty and the later adult phase of life. Dr. Kesić also studies the electrical activity of neurons with the application of sophisticated methods of biosignal analysis, such as fractal analysis. He is also involved in the philosophy of biology, philosophy of science, and theoretical-philosophical aspects of understanding complex biological systems.
He received a FENS/IBRO scholarship to participate in the "IBRO Summer Training School in Neuroscience: Neuroimaging and complementary Techniques" in Belgrade 2008 and the 7th FENS Forum in Amsterdam. A short visit to Moscow's Institute for Problems of Information Transmission at the Russian Academy of Sciences and Arts. Lecture at the Faculty of Computer Mathematics and Cybernetics at Lomonosov University in Moscow, Russian Federation.
Dr. Kesić is a member of the BioEM Society, the Federation of European Neuroscience Societies (FENS), the Neuroscience Society of Serbia, the Serbian Biological Society, and the Biophysical Society of Serbia. He is a reviewer in several journals on the SCI list and proposals for the New Millennium Nucleus projects of the Republic of Chile. He is a guest editor in Frontiers in Physiology. Dr. Kesić is the coeditor of one book.
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
Ecophysiology studies the physiological processes in living beings that are a response to changes in the external environment and that are fundamental to understanding the mechanisms and interactions that underlie the adaptive strategies of organisms. The effect of climate change, the presence of various pollutants, the availability of nutrients, and habitat degradation are some of those influences that are studied.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Nevena (Raičević) Zogović graduated from the Faculty of Biology at the University of Belgrade, majoring in Molecular Biology and Physiology. She enrolled in postgraduate studies at the same faculty, majoring in Immunobiology. She defended her M.Sc. thesis, entitled "Functions of rat macrophages in an experimental model of different severity trauma" in 2002 and her PhD thesis, entitled "Mechanism of cell death caused by oxidative stress in astrocyte culture: the role of nitrogen monoxide and iron" in 2006. In 2000-2001, Dr. Zogović was employed at the Department of Biology, Faculty of Veterinary Medicine, UB. Since 2001, she holds a permanent position at the Institute for Biological Research "Siniša Stanković" – National Institute of the Republic of Serbia, UB. At present, she is a Senior Research Associate.
Dr Zogović's research is focused on molecular and cellular mechanisms underlying cell-based models of cancer and neurodegeneration, as well as on the potential benefits of novel therapeutics for these diseases. In recent years, using state-of-the-art biochemical and molecular methods, her research has been directed toward revealing the role of autophagy, oxidative stress, mitochondria, and cell death, and their regulation as prospective therapeutic targets.
From 2008 to 2009, Dr Zogović was engaged as a postdoc on the FP6 project „Reinforcing a centre for laser microscopy and cell profiling for regional networking – NEUROIMAGE“, enabling her to visit the Laboratory of Professor Gian Micheale Ratto, Scuola Normale Superiore, Pisa, Italy as visiting scientist where I was trained in confocal microscopy.
Dr Nevena Zogović received a fellowship for advanced graduate students, of the Ministry of Science, Technology and Development of the Republic of Serbia (year 2000). Dr Zogović is the first laureate of the award for a young scientist in the field of physiology and/or biophysics of the Foundation "Akademik Radoslav K. Anđus" for 2005.
Dr Zogović is a member and one of the founders of the Optical Society of Serbia. She is also a member of the Serbian Biological Society (a member of the Scientific Board), the Serbian Neuroscience Society (SNS), Society for Neurosciences of Serbia, the Serbian Society for Mitochondrial and Free Radical Physiology, the Serbian Society for Molecular Biology (MolBioS), Federation of European Neuroscience Society (FENS), and the European Society for Free Radical Research (SFRR-E).
Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.
Ecophysiology studies the physiological processes in living beings that are a response to changes in the external environment and that are fundamental to understanding the mechanisms and interactions that underlie the adaptive strategies of organisms. The effect of climate change, the presence of various pollutants, the availability of nutrients, and habitat degradation are some of those influences that are studied.
Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Education
• 2009, PhD in Multidisciplinary Sciences - Neuroscience, University of Belgrade.
• 2001-2003, Researcher at the Department of Cellular and Molecular Physiology, Yale University, Connecticut, USA.
• 2000-2001, Research Fellow in the Pain Laboratory, Department of Gastroenterology, UTMB, Texas, USA.
• 1996 University of Belgrade, Faculty of Biology, B.Sc. Molecular biologist and physiologist, majoring in Biophysics.
Research interests
Application of electrophysiological techniques in order to elucidate the mechanisms of regulation of ion transport through the cell membrane.
Part of the work in our laboratory is aimed at investigating the physiological role and modulation mechanisms of ion channels. Ion channels in the cell membrane act as molecular transducers - in response to various stimuli (chemical, mechanical or electrical) the channel pore opens, allowing ions to pass through the membrane. The activity of ion channels is pivotal for many physiological processes, including the transmission of nerve impulses and transport across epithelia. They are key elements of cell membrane physiology in all cell types, regardless of the organism or kingdom of life. Recently, I have focused on studying the activity of ion channels in the membranes of filamentous fungi, which are poorly characterized compared to ion channels in other groups of organisms. Using the patch clamp, it is possible to carry out such investigations only on the specific experimental models. To open up this field, we are developing, in collaboration with colleagues from other institutions, a new experimental approach to study the activity of ion channels in filamentous fungi that enables the reliable high-resolution recording of ion currents in filamentous fungi.
Projects
• Work package coordinator for the project "Advanced BioPhysical Methods for Soil Targeted Fungi-Based Biocontrol agents" (BioPhysFUN) within the Green Program, Science Fund of the Republic of Serbia.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Mycology is the study of fungi that investigate their genetics, growth, structure, and interactions with other organisms in an ecosystem. The areas of mycological research at the Institute include medicinal mycology, phytopathology, description of new species and their potential application in biotechnology and industry.
Microbiology studies the structure, function, genetics, and ecology of microorganisms, including bacteria, viruses, fungi, and protozoa. Within the Institute, important areas of microbiological research include medical microbiology, environmental microbiology and industrial microbiology.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Maja Misirkić Marjanović successfully defended her doctoral dissertation titled "Mechanisms of cytotoxic and cytoprotective action of fullerene (C60) nanoparticles" at the Faculty of Medicine, University of Belgrade, in 2015. She had previously earned her Master in Molecular Biology and Physiology from the Faculty of Biology at the same university in 2005. Dr. Misirkić Marjanović's research significantly contributes to understanding the antitumor and immunomodulatory potential of nanoparticles. Her work focuses on investigating the mechanisms and impact of autophagy on the antitumor properties of newly synthesized compounds, neuronal and leukemic cell differentiation processes, and SARS-CoV-2 infection. She collaborated on writing a review paper on guidelines in autophagy investigation published in the scientific journal Autophagy. Her expertise led to invitation to contribute to the fourth version of these guidelines due to the importance of her previous research. These guidelines aid researchers in selecting appropriate methods for studying autophagy and its related processes, and interpreting their findings.
Dr. Misirkić Marjanović received the "Veselin Lučić" Endowment Award in 2022 for outstanding scientific achievements as a faculty member at the University of Belgrade. Additionally, a doctoral dissertation she supervised, authored by Dr. Miloš Mandić, won the "Ivan Đaja" award for the best dissertation in physiology. She also managed a work package "Optimized protocols for cell transfection and treatment" of Science Fund of the Republic of Serbia's special call for COVID-19 research January 2021-November 2022. From 2021 to 2023, she led project tasks focused on understanding the role and mechanisms of autophagy induction in HL-60 cell differentiation induced by PMA.
Dr. Misirkić Marjanović is a member of various scientific societies, including Serbian Society for Molecular Biology, Serbian Biological Society, Society for Neuroscience of Serbia, Federation of European Neuroscience Societies, Nordic Autophagy Society, and the Women in Autophagy network. She participated in the COST actions TRANSAUTOPHAGY and TRANSLACORE.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Mycology is the study of fungi that investigate their genetics, growth, structure, and interactions with other organisms in an ecosystem. The areas of mycological research at the Institute include medicinal mycology, phytopathology, description of new species and their potential application in biotechnology and industry.
Microbiology studies the structure, function, genetics, and ecology of microorganisms, including bacteria, viruses, fungi, and protozoa. Within the Institute, important areas of microbiological research include medical microbiology, environmental microbiology and industrial microbiology.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Ljubica Vučićević graduated 2005, at the Faculty of Biology University of Belgrade in Molecular Biology and Physiology. She defended her doctoral dissertation entitled "The role of adenosine monophosphate-activated protein kinase inhibition in the induction of apoptosis and autophagy in tumor cell lines" at the Faculty of Biology of the University of Belgrade in 2013. She received the "Goran Ljubijankić" award for the best doctoral dissertation in the field of molecular biology in 2013. As a member of a national research project OI173053 she coordinated the project task entitled “Investigation of the role of autophagy in the antitumor effect of experimental drugs in the therapy of human neuroblastoma”. In 2016, she was the winner of the national scholarship program “Start Up for Science”, for the project “Modulation of intracellular energy balance-controlling signaling pathway and autophagy in an in vitro model of cerebral ischemia”. In 2017, she was on a short postdoctoral research training at the Institute for Cell & Molecular Biosciences (Newcastle University, UK). Within the special research program for COVID-19 of the Science Fund of the Republic of Serbia (2021. - 2022) as a member of a project ,,Targeting Autophagy to Combat SARS-CoV-2-induced Immune Dysregulation“, she coordinated working package entitled „Modulation of autophagy and immune response by SARS-CoV-2 proteins“. At the contest of the "Veselin Lučić" Endowment for the best scientific achievement for the year 2022, she was awarded as a co-author for an article “MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia cells”. She is involved in the research of the macroautophagy process and so far has studied the role and mechanisms of autophagy in starvation, oxidative stress, excitotoxicity, inflammation, differentiation and cancer therapy. She participated in COST actions Transautophagy CA15138, and in Translacore CA21154 as a MC member. She is a member of Serbian Society for Molecular Biology, Serbian Biological Society, Serbian Neuroscience Society, Federation of European Neuroscience Societies, and Women in autophagy.
Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.
Mycology is the study of fungi that investigate their genetics, growth, structure, and interactions with other organisms in an ecosystem. The areas of mycological research at the Institute include medicinal mycology, phytopathology, description of new species and their potential application in biotechnology and industry.
Microbiology studies the structure, function, genetics, and ecology of microorganisms, including bacteria, viruses, fungi, and protozoa. Within the Institute, important areas of microbiological research include medical microbiology, environmental microbiology and industrial microbiology.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Ljubica Harhaji Trajkovic, a Principal Research Fellow, was born in Belgrade in 1976. She earned a B.Sc. in Molecular Biology and Physiology (2001), an M.Sc. (2004) and a Ph.D. (2006) at the Faculty of Biology, University of Belgrade. Dr. Harhaji Trajkovic completed postdoctoral training at the Panum Institute, University of Copenhagen, Denmark in 2007. In 2011, she received the L'Oréal-UNESCO “For Women in Science Awardsˮ. Ljubica was the leader of the project “The role of autophagy in tumor cell death" (2011 to 2019), funded by MESTD. She is currently leading the project "Dual targeting of lysosomal stability and energy metabolism as a novel antimelanoma strategy", for which she received a donation from the non-profit international organization “Climbers Against Cancer”. Her research interests include cancer biology, neurophysiology, cancer cell metabolism, autophagy, and lysosomal cell death. Ljubica is co-author of 67 scientific articles published in international journals, which have been cited more than 9000 times.
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Ljiljana Nikolic received a Ph.D. degree from the Faculty of Biology, University of Belgrade, in 2012. During her doctoral studies, she also spent some time at the Institute of Physiology ASCR v.v.i in Prague in the laboratory of Dr. Hana Zemkova. Dr. Nikolic completed post-doctoral training in the neuron-glia interactions research group in the laboratory of Dr. Etienne Audinat at the Paris Descartes Faculty of Medicine. In 2018, Dr. Nikolic returned to IBISS in the Department of Neurophysiology, where she is now a Principal Research Fellow.
Research Focus: Understanding the interactions between the cells of the CNS is crucial to understanding how the brain works. I am interested in understanding the communication of a particular type of glial cell astrocytes with other cells in the CNS in the healthy brain and in animal models of brain disease. Astrocytes are glial cells that form dense networks throughout the CNS. This places them in a unique position to interact with neurons, immune cells, other glial cell types and blood vessels. I am investigating the mechanisms and signals by which astrocytes engage in the cell-cell interactions by combining live cell imaging with patch-clamp technique.
Honors and Awards:
I received a Fellowship Start-up Award from the Centre for Leadership Development to perform scientific research in the field of Medicine and Life Science in 2018.
I received Academician Radoslav K. Andjus Foundation award (FARKA) for creative young investigator in Physiology and Biophysics in 2012.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Education:
• Ph.D. (Faculty of Biology, University of Belgrade, 2013.)
• M.Sc. (Faculty of Biology, University of Belgrade, 2004.)
• B.Sc. (Faculty of Biology, University of Belgrade, 1999.)
Research interests:
• Electrical activity of animals brain
• Animal behavior
Work experience:
• Since 2001, employed at the Institute for Biological Research, Department of Neurobiology, Department of Neurophysiology
Memberships in scientific societies:
• Serbian Biology Society
• Society for Neurosciences of Serbia
• FENS
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Kristina Janjetović has finished her PhD thesys "The effect of metformin on the apoptosis of glioma and melanoma cells in vitro and on melanoma growth in vivo" in 2014 at the Faculty of Medicine, University of Belgrade. She graduated in 2002, at the Faculty of Biology at the University of Belgrade in Molecular Biology and Physiology. Dr. Kristina Janjetović studies new approaches in tumor therapy: molecular and cellular mechanisms underlying the cytotoxic effect of new antitumor compounds in vitro and the role of autophagy and its modulation in different pathologies. She was on scientific specialization from 2003 to 2005 at the Institute of Pathophysiology, Medical University of Innsbruck, and during her training in Austria, in 2004, she received an award from the Osterreichische Krebshilfe for research funding "The role of the tumor suppressor PTEN in the development of leukemias and apoptosis of leukemias induced by glucocorticoids" and in 2005 for the research "Functional analysis of new candidate genes selected from comparative profiling of lymphoblasts in children with acute lymphoblastic leukemia". The doctoral dissertation of Dr. Marina Stamenković, whose candidate was a commentor, was awarded with "Goran Ljubijankić Foundation" in 2021. From 2019-2021 she was the project leader "Molecular mechanisms of action of pantoprazole on the induction of apoptosis and/or autophagy in non-small cell lung cancer (NSCLC) in vitro", funded by the Phillip Morris company as part of the "Start up for Science" program. From 2021-2023. she was responsible for project tasks: "The role of pantoprazole, a proton pump inhibitor, in the regulation of autophagy and apoptosis in the NSCLC H460 cell line" and "Establishment of a methodology for the transfection of the human neuroblastoma cell line SHSY-5Y with plasmids carrying mutations in the amyloid-β protein precursor gene (Swedish ,751, wild-type), as an in vitro model of Alzheimer's disease".
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
Scientific expertise:
• Prenatal influence of antiepileptics and neurobehavioral postnatal development
• extrasynaptic vesicles and epigenetic modifications througout generation
• maternal condition with effect on offspring development
• EEG and ECoG of rodents under various conditions
Working experience:
• 2015.- Research Associate – Department of Neurophysiology, Institute for Biological Research “Siniša Stanković”
• 2011.- Research Assistant – “Neurological development of the offspring exposed to antiepileptic therapy”. P175006 (2011- 2021)
• 2008.- Research Assistant – “Effect of the traumatical, neurotoxical and neuroprotective substances on the electrical activity of mammals brain. Analysis and modelling. P143021 (2006 -2010)
Education:
• 2014.- PhD “Influence of the valproic acid during gestation on the animal model of the mouse – effect on the behavior and motor development of the offspring“. Medical faculty, University of Kragujevac
• 2007.- Doctor of Medicine - Medical faculty, University of Belgrade
Membership in profesional association:
• Serbian Medical Society
• Serbian Biological Society
• Serbian Neuroscience Society
• FENS
COST Actions:
• CA22114 „Maternal Perinatal Stress and Adverse Outcomes in the Offspring: Maximizing infants development”
• BM0601 (NeuroMath)
• BM0605 (On Consciousness)
Reviewer activity
Invited review activity in World Journal of Pediatrics
Fellowship:
• Symposium: ”Harnessing the Power of advanced Technologies for Group-Housed Animal Research”, Granada, 2023.
• “High Throughput Communication between Brain and Machines” COST Action NeuroMath (BM0601) (Greece)
• “Consciousness of the self – Consciousness of others” COST (BM0605) Corsica (France)
Oral Presentations and Leactures:
2016.- Podgorac J. “Quantitative and qualitative assessment of the offspring in the Tail suspension test (TST) which mothers were treated with different doses of valproic acid during entire pregnancy. 7th Global Annual Meet on Neurology and Neurosurgery. Vienna, Austria, 2016.
2012.- Podgorac J. “Effect of valproic acid on neurodevelopment of mice during gestation”. 17th Multidisciplinary International Conference on Neuroscience and Biological Psychiatry “Stress and Behavior”. St-Petersburg, Russia, 2012;
2011.- Podgorac J. “Toxic effect of the antiepileptics on the cerebellum“. Brain awareness week in Serbia, 2011.
2010.- Podgorac J. “Animal models of depression”. Brain awareness week in Serbia, 2010.
Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.
Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.
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Fax: +381 11 27 61 433
Email: ibiss@ibiss.bg.ac.rs
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Serbia
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