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Friday, 19 January 2024 11:40

Dr. Desanka Milanović

Dr. Milanovic is a molecular biologist specialized in neurobiology. Her work has involved investigation of molecular mechanisms underlying neurotoxicity of anesthetics during development, and nutritive approaches in ameliorating aging, neuro-inflammation and Alzheimer’s disease.

Friday, 19 January 2024 11:40

Dr. Danijela Savić

Scientific position
• Principal Research Fellow, 2022.

Education
• Ph. D. (Neurobiology, Faculty of Biology, University of Belgrade, 2012)
• M. Sc. (Neurobiology, Faculty of Biology, University of Belgrade, 2005)
• B. Sc., Molecular Biology and Physiology, Faculty of Biology, University of Belgrade 2002)

Research interests
• Neuroinflammation
• Neuroendocrinology
• Neurodegenerative diseases

Supervision
Current
• „Antioxidative and antiinflammatory effect of agmatine pretreatment in LPS-activated mouse microglial cell line“, Ph.D. – Principal Advisor
Completed
• „The role and metabolism of copper in human hippocampal sclerosis associated with temporal lobe epilepsy”, Ph.D., 2022. – Principal Advisor
• „Spatial and time-dependent expression of cholesterol-24-hydroxylase in the spinal cord during experimental autoimmune encephalomyelitis, M. Sc., 2016. – Principal Advisor
• „Expression of panexin and P2X7 receptor after traumatic brain injury induced in rats”, M. Sc., 2013. – Principal Advisor

Fellowships
• COST-STSM-B30-04014 Grant for Short Term Scientific Mission from within a COST scientific program on Neuronal Regeneration and Plasticity: NEREPLAS in Institute of Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany, 2008.

Memberships
• Federation of European Neuroscience Societies, Serbian Neuroscience Society, Serbian Biological Society.

Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.

Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.

Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.

Friday, 19 January 2024 11:40

Dr. Ana Podolski-Renić

EDUCATION:
2013. PhD degree in Biology, University of Belgrade, Faculty of Biology, Serbia
2006. BSc degree in Molecular Biology and Physiology, University of Belgrade, Faculty of Biology, Belgrade, Serbia

RESEARCH EXPERIENCE: Head of the Laboratory of Molecular Neuro-Oncology at the Institute for Biological Research "Siniša Stanković" - National Institute of the Republic of Serbia (IBISS); employed at IBISS in 2007 as a research trainee in the Department of Neurobiology; in 2009 appointed as a research assistant, in 2014 as a research associate and in 2019 as a senior research associate.

RESEARCH FIELD: Investigating the mechanisms of action of new antitumor agents with the potential to overcome multidrug resistance in cancer and developing new therapeutic approaches for the treatment of malignant tumors.

PROJECT HISTORY: Work package leader of the "TargetedResponse" project funded by the IDEJE program of the Science Fund of the Republic of Serbia and work package coordinator of the "MilkIng" project“, a strategic project of SANU; participation in the "PhotoSCLART" project funded by the PRIZMA program of the Science Fund of the Republic of Serbia; participated in two international multidisciplinary projects: „Therapy optimization in glioblastoma: An integrative human-data based approach using mathematical models“ (funded by the James S. McDonnell Foundation) and “THIOREDIN” (ERA.Net RUS+ project); member of the Management Board of COST Action CA22125 (Precision-BTC-Network) and management board member substitute for two completed COST Actions: CM1407 (NATCHEMDRUGS) and CA17104 (STRATAGEM).

AWARDS, PRIZES AND FELLOWSHIPS: Fellowship of European Association for Cancer Research (EACR) for participation in the ESMO Congress 2017 in Madrid; Award of Foundation “Goran Ljubijankic” for the best doctoral thesis in molecular biology defended in 2013; Fellowship of COST Action BM0703 (CANGENIN) to attend the Biomedical Research Foundation of the Academy of Athens in Greece, 2010.

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Dr. Aleksandra Mladenović

Dr. Aleksandra Mladenovic is a research professor at the Institute for Biological Research "Sinisa Stankovic", University of Belgrade. She received her B.Sc. in Molecular Biology and Physiology from the Faculty of Biology, University of Belgrade in 1998. Holding a prestigious scholarship for her postgraduate studies, awarded to the 200 best students in the country, she obtained her M.Sc. in 2002, followed by a Ph.D. in Neuroscience in 2008.

In 2003, she got a permanent position at Laboratory of Molecular Neurobiology, where she worked on neurodegenerative diseases, apoptosis and synaptic plasticity. Dr. Mladenovic deepened her knowledge through postdoctoral training at the Laboratory for Molecular and Cellular Ageing, NHRF Institute, Greece.

Dr. Mladenovic is an Associate Editor of high-ranking journals such as BioFactors (Q1) and Mechanisms of Ageing and Development (Q1), one of the oldest and most important journals in the field of ageing. She is also an Associate Editor for FEBS Open Bio.

She has been a Serbian representative in several COST Actions and is actively involved in the Serbian Neuroscience Society and the global ALBA network of neuroscientists. She is a member of the Scientific Committee of the European Society of Preventive, Regenerative, and Anti-Aging Medicine.

She was the Serbian leader in three international projects with Switzerland, Croatia and the UK. She was also awarded with FEBS and IUBMB grants for the organization of Advanced Course "Molecular Targets for Anti-Aging Interventions", which took place in 2022 on the island of Spetses, Greece.

She has been a guest speaker at several international conferences. She is a reviewer for more than 15 journals and is actively involved in the supervision of PhD and Master students.

Currently, her research focuses on exploring promising anti-aging interventions, with particular emphasis on optimizing nutritional patterns for healthy ageing, and paying special attention to the nervous system.

Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.

The biology of ageing is focused on better understanding the molecular, cellular and physiological processes underlying the ageing process and the diseases associated with this process.

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.

Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.

Metabolism is the totality of all chemical reactions that provide energy to cells and maintain the vital state of cells and organisms. Metabolism is a tightly regulated process, and control of metabolic pathways allows organisms to successfully interact with their environment. Metabolic regulation is key to understanding and treating a number of chronic diseases, including diabetes, obesity, hypertension, and cancer.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Friday, 19 January 2024 11:40

Anica Živković

Education:
Doctorate, Faculty of Biology, University of Belgrade (since 2021)
MsC, Master studies, Faculty of Biology, University of Belgrade (2019-2020)
BsC, Bachelor studies, Faculty of Biology, University of Belgrade (2015-2019)

Interests: neurobiology, immunobiology

Memberships:
Serbian Neuroscience Society (SNS)
Federation of European Neuroscience Societies (FENS)

Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Anđela Vukojević

Anđela Vukojević, third year PhD student at the Department of Molecular Biology, Faculty of Biology, University of Belgrade, (study program: Molecular Biology, module: Physiology, submodule: Animal and Human Physiology). She completed her undergraduate studies at the Department of Biology, Faculty of Science and Mathematics, University of Niš and graduated in 2018. She continued her master's studies at the same institution and achieved an overall grade point average of 9.27 in 2020. After her master's studies, Anđela completed an internship in the microbiology department of the Medicus Universalis health center in Kruševac. In 2021, she started her doctoral studies and began employment at the Institute for Biological Research "Siniša Stanković". Her research focuses on investigating the effect of fermented foods on the central nervous system. Her dissertation, is entitled "Effect of pretreatment with sauerkraut brine of a defined composition on oxidative stress and inflammatory processes trough the action of lipopolysaccharide in mice". In addition to her academic activities, Anđela is actively involved in the scientific community as a member of societies, including the Society for Neuroscience of Serbia (DNS), the Federation of European Neuroscience Societies (FENS), the Serbian Society for Molecular Biology (MolBioS) and the European Cooperation in Science and Technology (COST). She is actively involved in the PIMENTO COST Action, Promoting Innovation of Fermented Foods (CA20128), in the E7 project “PIMENTO E7: The Effects of Lactobacillus sp and/or Bifidobacterium sp in Fermented Foods on Cognitive Health: A Systematic Review”. As part of the same project, she was also involved in the development and implementation of the Fermented Food Questionnaire (FFFQ). She was a participant of the joint FEBS/IUBMB advanced course “Molecular Targets for Antiaging Interventions” in Spetses, Greece, 2022, supported by COST Action ITC Conference Grant. She was awarded the "IUBMB Life Poster Award" at @FebsIUBMB2022 event.

Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Nutrition is the process by which the body uses food to produce energy and sustain life. The science of nutrition studies the role of nutrients and other food components in the growth, reproduction, health and disease of the organism. Food ingredients with medicinal properties are called nutriceuticals and can be used to treat or prevent disease. There are more and more alternative sources of food, such as edible insects, which should limit the negative impact of food production on the environment.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Andrea Novaković

Andrea Novaković is a second-year PhD student at the Faculty of Biology, University of Belgrade. She is currently employed as a Research trainee at the Department of neurobiology at the Institute for biological research ,,Siniša Stanković", National Institute of the Republic of Serbia, University of Belgrade.

Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Ana Stepanović

Ana Stepanović holds a master’s degree in molecular biology, from Faculty of Biology, University of Belgrade. She was awarded for the best master thesis in molecular biology by the Foundation "Goran Ljubijankić." She is a fourth-year PhD student at the Faculty of Biology, specializing in physiology - Translational research in neurobiology and biomedicine. She started her doctoral studies in 2020. Her PhD thesis focuses on the development of new hybrid compounds of sclareol and doxorubicin and testing their anticancer properties under the mentorship of Dr. Milica Pešić. Part of the thesis results are submitted in national and PCT patent applications "Hybrid compounds of sclareol and doxorubicin, their synthesis and application“, Priority date: November 14th, 2022, PCT Application No: PCT/RS2023/000016. Additionally, Ana is a team member on two projects funded by the Science Fund of the Republic of Serbia, "PhotoSCLART" project: development of nature-inspired photoresponsive anticancer agents - sclareol and artemisinin derivatives in cancer multidrug-resistance models: a foundation for the theranostic approach" and "TargetedResponse" project: Functional diagnostics in non-small cell lung carcinoma—a new concept for the improvement of personalized therapy in Serbian patients. Ana is also a member of the IBISS project "Proof of Concept" "Innovative hybrid compounds of sclareol and doxorubicin as new antitumor strategy in glioblastoma therapy" (SCLarDOXInn) and team member of Serbian Academy of Sciences (SANU) project entitled "Biomedical potential of newly isolated diterpenes of milk thistle latex in Serbia". She was a member of the Organizing Committee in the sixth congress of SDIR, "From Collaboration to Innovation in Cancer Research" in 2023, and COST Action CA17104, "New diagnostic and therapeutic tools against multidrug-resistant tumors" in 2020. Ana is a member of the Serbian Society of Cancer Researchers, the European Association of Cancer Research, the Society for Neuroscience of Serbia, and the Federation of European Neuroscience Societies.

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Friday, 19 January 2024 11:40

Dr. Ana Milošević

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Stefan Marković Hadžić

Education:
Doctoral academic studies, Faculty of Biology, University of Belgrade; 2022
Master's academic studies, Faculty of Biology, University of Belgrade; 2022
Undergraduate academic studies, Faculty of Biology, University of Belgrade; 2021

Research Experience:
2022 – Preparation of doctoral thesis, Department of Molecular Biology, Institute for Biological Research "Siniša Stanković."
2021-2022 – Preparation of master's thesis, Department of Plant Physiology, Institute for Biological Research "Siniša Stanković."

Research Area:
Utilization of various constructs based on the CRISPR/dCas system aiming at silencing the Aristaless-related homeobox gene (ARX) and production of insulin-secreting cells.

Membership in Scientific Societies:
Member of the Serbian Society for Molecular Biology.
Participant in the science promotion event "Researchers' Night 2023."

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

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