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Friday, 19 January 2024 11:40

Dr. Miodrag Dragoj

Dr. Miodrag Dragoj graduated in 2013 from the Faculty of Biology at the University of Belgrade, specializing in Molecular Biology and Physiology. In the academic year 2013/2014, he enrolled in doctoral studies in Molecular Biology, focusing on the Molecular Biology of Eukaryotes, at the University of Belgrade - Faculty of Biology. He has been employed at the Neurobiology Department of the 'Siniša Stanković' Institute for Biological Research at the University of Belgrade since July 2014.

During his doctoral studies, he conducted scientific research through the project 'Identification of molecular markers for predicting tumor progression, response to therapy, and disease outcome' (III41031), funded by the Ministry of Education, Science, and Technological Development of the Republic of Serbia. He completed his doctoral thesis, titled 'Effects of CXCR4 receptor and focal adhesion kinase inhibition in invasion suppression and overcoming resistance in non-small cell lung cancer,' obtaining the title of Doctor of Biological Sciences on October 9, 2018. He received the 'Goran Ljubijankić' Foundation award for the best doctoral thesis in molecular biology defended in 2018 in Serbia.

After his PhD, he represented Serbia in two international interdisciplinary projects: 'Optimization of glioblastoma therapy' (funded by the American James S. McDonnell Foundation) and 'Development of thioredoxin reductase inhibitors as new anti-cancer agents' (ERA.Net RUS+ project).

Dr. Dragoj currently leads a project work package in the project from IDEJE program titled 'Functional diagnostics of non-small cell lung cancer - a new concept for improving personalized therapy in Serbia' (TargetedResponse) and in the PRIZMA program titled 'Biomimetic tumor engineering to enhance drug discovery' (BioengineeredTumor), both supported by the Science Fund of the Republic of Serbia.

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Biotechnology is defined as the use of biological processes and systems (living organisms or their parts) to develop or modify different processes or products useful to humans and includes analysis of risks of its implementation (biosafety).

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Friday, 19 January 2024 11:40

Dr. Milka Perović

Scopus Author ID: 8944418500

Summary:
Principal Research Fellow in the Laboratory for Molecular Neurobiology and Behavior, with more than twenty years of research experience in molecular neurobiology. Author/coauthor of more than 30 peer-reviewed publications. Mentor of PhD and MSc students.

Research Focus:
The main focus of Dr. Perovic's research is on the molecular mechanisms underlying brain plasticity during aging and in age-related neurodegenerative disorders, particularly in Alzheimer’s disease (AD). By combining various biochemical, molecular, and histological approaches, she extensively studied the role of synaptic plasticity, inflammation, gliosis, cholesterol metabolism, stress-related, and BDNF signaling in age-related neurodegenerative changes. Her long-term goal is to understand how these mechanisms can be altered by different environmental and pharmacological interventions and to implement this knowledge into the search for novel and/or more effective AD therapies.

Education:
• B.Sc. in Molecular Biology and Physiology, Faculty of Biology, University of Belgrade, 1998
• M.Sc. in Biological Sciences, Faculty of Biology, University of Belgrade, 2002
• Ph.D. in Biological Sciences, Faculty of Biology, University of Belgrade, 2011

Honors and Awards:
• Fellowships for Advanced Postgraduate Students, Ministry of Science, Technology and Innovation of the Republic of Serbia, 1999 - 2002
• German Academic Exchange Service (Deutscher Akademischer Austauschdienst - DAAD) short-term fellowship, 2008
• High ranking scientist (A1), Ministry of Science, Technology and Innovation of the Republic of Serbia, 2011 - 2024
• Best PhD Thesis in Molecular Biology Award in 2011 - Foundation ”Goran Ljubijankić”

Society memberships:
Serbian Neuroscience Society (SNS), FENS - Federation of European Neuroscience Societies, Serbian Society for Microscopy, European Microscopy Society, Serbian Biochemical Society, American Heart Association (AHA)

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Biotechnology is defined as the use of biological processes and systems (living organisms or their parts) to develop or modify different processes or products useful to humans and includes analysis of risks of its implementation (biosafety).

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Friday, 19 January 2024 11:40

Dr. Marija Janjić

Research interest
Reproductive endocrinology, neuroendocrinology, neuroinflammation

Education
2005: BSc Biology, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Republic of Serbia.
2012: Ph.D. Biochemistry, Department of Chemistry, Biochemistry and Environmental Protection; Faculty of Sciences University of Novi Sad, Republic of Serbia.

Work experience
2006-2013: Junior research assistant, research assistant, teaching Assistant, Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Republic of Serbia.
2013-2017: Assistant professor, Laboratory for Reproductive Endocrinology and Signaling, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Republic of Serbia.
2017-present: Senior Research Associate, Department of neurobiology, Institute for Biological Research “Sinisa Stankovic”, National Institute of the Republic of Serbia, University of Belgrade, Republic of Serbia.

Education abroad
2014-2017: Visiting Fellow, National Institutes of Health (NIH), National Institute of Child Health and Human Development (NICHD), Section on Cellular Signaling, Bethesda, Maryland, USA. Grant: ZIA HD000195-22, “Signaling and secretion in neuroendocrine cells”, Intramural Research Projects, funded by NIH, USA.
2020-2021: Postdoctoral Fellow, Children's National Medical Center, Children's Research Institute, Center for genetic medicine research, Washington DC, USA. Grant: 5R21TR003166-02, “Systemic biomarkers of brain injury from hyperammonemia”, funded by NIH, USA.

Awards
2006 -2008: Scholarship holder of the Ministry of Science, Republic of Serbia
2009 IUBMB/FEBS: Young Scientist Forum participation grant, Shanghai, China
2010 FEBS: Young Scientist Forum participation grant, Gothenburg, Sweden

Memberships
Serbian Neuroscience Society (SNS), Federation of European Neuroscience Societies (FENS), The European Society of Endocrinology (ESE)

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Dr. Maja Srbovan

Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Dr. Jelena Petrović

Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Dr. Jelena Dinić

EDUCATION: Ph.D. in Cell biology, The Wenner-Gren Institute, Faculty of Science, Stockholm University, Sweden, 2011. B.Sc. in Molecular biology and physiology, Faculty of Biology, University of Belgrade, 2004.

RESEARCH INTERESTS: Mechanisms of multidrug resistance in cancer and the development of new therapeutics targeting these mechanisms.

WORK EXPERIENCE: Department of Neurobiology, Institute for Biological Research “Siniša Stanković” since 2012. The Wenner-Gren Institute, Stockholm University (2005-2011).

PROJECTS: “Functional diagnostics in non-small cell lung carcinoma−a new concept for the improvement of personalized therapy in Serbian patients” (TargetedResponse,#7739737, 2022-2025), Science Fund of the Republic of Serbia IDEAS; “Biomimetic tumor engineering to enhance drug discovery” (BioengineeredTumor,#7503, 2024-2026), Science Fund of the Republic of Serbia PRISMA; „Biomedical potential of diterpenes newly isolated from latex of milkweeds (Euphorbia L.) wild-growing in Serbia“ (MilkIng, 2022-2025), SASA strategic project; “Innovative hybrid compounds of sclareol and doxorubicin as a new antitumor strategy in glioblastoma therapy” (SCLarDOXInn,2023-2024), SAIGE Proof of concept; “Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome” (#III41031, 2011-2019), Ministry of Education, Science and Technological Development of the Republic of Serbia.

European Cooperation in Science and Technology (COST) Actions: CA22103: A comprehensive network against brain cancer (Net4Brain;2023-2027); IG17104: Pan-European educational platform on multidrug resistant tumours and personalised cancer treatment (PANDORA;2022-2023); CA17104: New diagnostic and therapeutic tools against multidrug resistant tumors (STRATAGEM;2018-2022); CA15138: European network of multidisciplinary research and translation of autophagy knowledge (TRANSAUTOPHAGY;2016-2020); CM1407: Challenging organic syntheses inspired by nature-from natural products chemistry to drug discovery (NATCHEMDRUGS,2015-2019); CM1106: Chemical approaches to targeting drug resistance in cancer stem cells (STEMCHEM;2012-2016).

MEMBERSHIPS IN SCIENTIFIC SOCIETIES: European Association for Cancer Research (EACR), Serbian Association for Cancer Research (SDIR), European Society for Medical Oncology (ESMO), Federation of European Neuroscience Societies (FENS), Serbian Neuroscience Society (DNS), Serbian Biological Society (SBS).

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Biotechnology is defined as the use of biological processes and systems (living organisms or their parts) to develop or modify different processes or products useful to humans and includes analysis of risks of its implementation (biosafety).

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.

Friday, 19 January 2024 11:40

Dr. Jelena Ćirić

Scopus Author ID: 55256030500

Summary:
Senior Research Associate in the Laboratory for Molecular Neurobiology and Behavior with more than thirteen years of research experience in the mechanisms of sleep disorders and the molecular neurobiology of ageing and various models of neurodegenerative disease. The focus of Dr. Ciric's research is on the effects of various pharmacological and non-pharmacological interventions that can delay the onset and/or progression of neurological diseases of the ageing brain, such as Alzheimer’s disease. Author/coauthor of more than 15 peer-reviewed publications.

Education:
• Ph.D. in Biological Sciences, Faculty of Biology, University of Belgrade, 2017
• M.Sc. in Biological Sciences, Faculty of Biology, University of Belgrade, 2010
• B.Sc. in Biological Sciences, Faculty of Biology, University of Belgrade, 2008

Honors and Awards:
• Figure 9 of the article entitled Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson disease neuropathology (Neuroscience, 2015, 304, 1-13) was selected for the Cover Winner, 2015
• Ciric et al., 2019, Front. Neurosci. was selected for the collection Sleep and Circadian Rhythms Editor’s Pick 2021, 2021
• Proposal entitled "Quantitative mapping of metals in KI mouse model of Alzheimer´s disease treated with synthetic neuroactive steroid" Award from Elettra Sincrotrone Trieste as part of the International Users Programme, 2023

Society memberships:
• Serbian Neuroscience Society (SNS)
• Federation of European Neuroscience Societies (FENS)
• Serbian Biochemical Society (SBS)
• Serbian Biological Society

Understanding the physiological and functional characteristics of cancer cells at the individual level, and the tumor tissue as a highly orchestrated multicellular formation, by whose activity the tumor expands, invades and disseminates, is the main goal of cancer biology research today. Defining the causes of abnormal behavior of neoplastic cells individually and in the context of the tumor microenvironment, including the histological, metabolic and immunological specificities of this tissue, represents a platform for designing new approaches in cancer treatment. Investigating the phenomenon of initial or acquired tumor resistance helps to gain deeper insights into the reasons for limited effects of the conventional treatments, enabling the improvement of existing protocols.

Biotechnology is defined as the use of biological processes and systems (living organisms or their parts) to develop or modify different processes or products useful to humans and includes analysis of risks of its implementation (biosafety).

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Natural products are complex chemical compounds synthesised by living organisms through biochemical processes, with a specific physiological or ecological function. Researchers at the Institute study the chemical characterization and isolation of natural products, metabolic engineering, as well as the assessment of the possibility of their application in industry (as medicaments, dietary supplements and functional food, biopesticides).

Redox biology is the study of all aspects of biology mediated or influenced by biochemical processes involving reduction (gain of electrons) and oxidation (loss of electrons). Redox homeostasis is central to the basic functions of life, including metabolism and respiration, and when altered it can promote the progression of disease and ageing.

Friday, 19 January 2024 11:40

Dr. Jasna Šaponjić

Jasna Šaponjić received MD degree in 1986, MSci degree in 1990 and PhD degree in 1996 at Medical School University of Belgrade, Republic of Serbia (former Yugoslavia).

After her postdoctoral period, first at the Department of Neurophysiology, of Medical School University of Patras, Greece (2000-2001), as a fellow of the European Concerted Action and Epilepsy Research (EUCARE, Brussels, Belgium) and at Medical School University of Illinois at Chicago (2001-2002), she was a Research Assistant Professor at the Department of Pharmacology and the Center for Narcolepsy Research at the Medical School University of Illinois, Chicago, USA (2003-2006).

She returned to the Institute for Biological Research – Sinisa Stankovic, first as Research Associate (2006-2007), then as Senior Research Associate (2007-2012).

Since 2012 she is Principal Research Fellow in the Department of Neurobiology at the Institute for Biological Research – Sinisa Stankovic, - National Institute of the Republic of Serbia, University of Belgrade, Republic of Serbia.

Her area of expertise is neuroscience and neurobiology of sleep. Her current research focuses on the neurobiology of sleep disorders and disturbances of motor control during sleep in in vivo animal models of healthy aging and neurodegenerative diseases of the elderly, in particular sleep disorders as a prodromal symptom of Parkinson’s disease and the risks of general anesthesia for postoperative outcomes in neurodegenerative diseases.

She has been a reviewer for numerous international journals, supervisor of three PhD theses and member of seven PhD thesis evaluation and defense committees between 2011 and 2024.

She is a member of ESRS, FENS, Serbian Neuroscience Society and Serbian Biophysical Society.

Behavioural biology studies animal behaviour at a systemic level by integrating behavioural, ecological, physiological, and molecular approaches to describe how different behavioral elements have been shaped through evolution.

The biology of ageing is focused on better understanding the molecular, cellular and physiological processes underlying the ageing process and the diseases associated with this process.

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Dr. Ivana Bjelobaba

Animal physiology studies how biological processes work, how they operate under different environmental conditions, and how these processes are regulated and integrated. They can be studied at different levels of organisation, from organelles and cell membranes to cells, tissues, organ systems, and the whole animal, both during development and in adulthood.

Inflammation is a response to damage and danger in organisms and is an integral part of research in immunology, but also in other scientific disciplines, since inflammation occurs in numerous pathological conditions like diabetes or cancer. Immunology studies body’s defence mechanisms at cellular and molecular level in infective diseases, as well as immune system malfunctions in autoimmune diseases and allergies Modification of body’s immune system is useful in treatment of these diseases, and can be performed through pharmacological modulation or immunotherapy, where immune cells or their parts are used. Acute-phase proteins and potential biological markers of inflammation involved in the modification and integration of signalling pathways are being investigated in order to predict and intervene in diseases.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

Friday, 19 January 2024 11:40

Dr. Irena Lavrnja

Irena Lavrnja, PhD, is currently a Principal Research Fellow at IBISS in the Department of Neurobiology. She graduated with a Bachelor's degree in Biology in 2000, defended her Master's thesis in 2003 and received her PhD in Neurobiology from the Faculty of Biology, University of Belgrade in 2008. During her career she held the following positions: Research Trainee (2001), Research Assistant (2003), Research Associate (2008), Senior Research Associate (2013), and since 2018 she is Principal Research Fellow at IBISS. Dr. Irena Lavrnja's research focuses on elucidating the cellular and molecular mechanisms underlying neuroinflammation, identifying potential targets and testing the efficacy of various therapeutic agents to suppress harmful and enhance beneficial inflammatory mechanisms. She utilises a variety of experimental approaches, including animal models of neuroinflammatory diseases such as experimental autoimmune encephalomyelitis and traumatic brain injury, in vitro cell culture systems, molecular and cellular biology techniques, and neuroimaging techniques. In 2010, she was awarded an STSM fellowship for postdoctoral studies by the European Commission (COST B30) at the Medical University of Innsbruck (Division of Neuroanatomy), Innsbruck, Austria, and in 2015 an EMBO short-term fellowship at the Karolinska Institute in Stockholm, Sweden. So far, she has been involved in solving 3 national projects and 2 international bilateral DAAD projects (German Knowledge Exchange Projects) and one project (Serbian Science and Diaspora Collaboration Programme: Knowledge Exchange Vouchers) funded by the Science Fund of the Republic of Serbia as Principal Investigator. Since 2018 she is a member of the Editorial Board of the journal ``Scientific Reports`` (Springer Nature Publishing AG), and since 2022 she is Review Editor for Frontiers in Cellular Neuroscience. She was supervisor of 2 PhD theses, both awarded as best PhD theses in physiology, and one Master thesis. As a committee member she was involved in 5 PhD theses and 2 Master theses.

Neurobiology studies the anatomy, physiology, and pathology of the nervous system. From the molecular and biochemical basis of this system, to the study of behavioral plasticity, to understanding the driving forces of neurodegenerative diseases and how they can be treated. Electrophysiology studies biophysical properties in vertebrate neurons and links morphofunctional features of the brain to observed animal behavior. The ultimate goal is to identify active substances that may have a protective effect in neurological and psychiatric diseases.

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