Project Website:

http://www.ltp-app-new.ipb.ac.rs/

Team leader:

Dr Nevena Puač, Institute of Physics, University of Belgrade

Team members

Dr Gordana Malović, Institute of Physics, University of Belgrade

Dr Nikola Škoro, Institute of Physics, University of Belgrade

Dr Marija Puač, Institute of Physics, University of Belgrade

Olivera Jovanović, Institute of Physics, University of Belgrade

Neda Babucić, Institute of Physics, University of Belgrade

Prof. Dr Dragana Vuković, Faculty of Medicine, University of Belgrade

Prof. Dr Maja Miletić, School of Dental Medicine, University of Belgrade

Dr Boško Toljić, School of Dental Medicine, University of Belgrade

Dr Suzana Živković, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade

Abstract:

A large variety of Atmospheric Pressure Plasma (APP) sources have been proven successful in applications in medicine, biology, stomatology, agriculture and food processing. Each of these devices was individually efficient in the targeted application. However, current knowledge in the applied fields of Plasma medicine and/or Plasma agriculture is insufficient to reach a general consensus on plasma parameters crucial for tailoring the chemistry responsible for the achieved results and whether or not they can be used for comparison between the APP sources. The scientific concept of APPerTAin-BIOM derives from the need to fill this gap in the knowledge. APPerTAin-BIOM aims to tackle following challenges: to create comprehensive plasma parameter database for APP sources operating in wide frequency range (with kHz-GHz power supplies) and to interlink plasma gas phase and sample liquid phase chemistry kinetics with obtained set of measurable plasma parameters and biomedical models (plant calli, drug resistant bacterial strains). In order to enclose these challenges, an extensive diagnostics of plasma systems will be performed and a detailed electrical model will be developed. The aim is to unify information from plasma physics and induced biochemistry in order to define standard protocols and procedures for treatments and give guidelines for comparison of different APP sources, which will be an important breakthrough for plasma biomedical treatments. The major scientific impacts of APPerTAin-BIOM will be: to significantly improve the understanding of the plasma chemistry at atmospheric pressure and the means for its tailoring; to define main plasma parameters that can be confidently used as markers for plasma efficiency. Wider impact of APPerTAin-BIOM is directed to the healthcare systems through providing a complete image of the innovative and cutting-edge biotechnological process that involves APP technology for drug-resistant bacteria.