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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Microbial Nanocellulose as an Effective Lactonase Immobilization Matrix for Enhanced Wound Healing

Chronic wounds pose a significant challenge due to bacterial biofilm infections and antibiotic resistance. Quorum-quenching enzymes like lactonases offer a promising therapeutic alternative. In this study, bacterial nanocellulose (BNC) is investigated as a biocompatible matrix for immobilization of YtnP lactonase, aiming to increase its efficacy against Pseudomonas aeruginosa. Two methods were employed: covalent cross-linking with glutaraldehyde (BNCL) and coordination with zinc ions (BNCML)...

Plastic Responses of Iris pumila Functional and Mechanistic Leaf Traits to Experimental Warming

Phenotypic plasticity is an important adaptive strategy that enables plants to respond to environmental changes, particularly temperature fluctuations associated with global warming. In this study, the phenotypic plasticity of Iris pumila leaf traits in response to an elevated temperature (by 1 °C) was investigated under controlled experimental conditions. In particular, we investigated important functional and mechanistic leaf traits: specific leaf area (SLA), leaf dry matter content (LDMC), specific leaf water content (SLWC), stomatal density (SD), leaf thickness (LT)...

Diagnostic Potential of CD44, CD133, and VDR in Epithelial Ovarian Tumors: Association with Histopathology Parameters

Cancer stem cells (CSCs) significantly contribute to heterogeneity, malignancy, and therapy resistance in ovarian cancer. Recent studies emphasize the role of the vitamin D receptor (VDR) in regulating cell differentiation and stemness in various types of cancer. This study aims to determine the expression levels of CD44, CD133, and VDR in epithelial ovarian tumors (EOTs) and to compare these levels across different tumor types, including benign, atypical proliferative tumors...

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