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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Development and evaluation approach of soil quality in agricultural soils: Integrated system for a more reliable delineation of homogeneous management zones

Soil quality (SQ) is of fundamental importance for sustainable agriculture, environmental conservation and food security. This study presents an integrative methodological framework for the assessment of SQ by combining indicators of soil properties with environmental variables. In a case study in Mali Zvornik, Serbia, agricultural SQ was assessed using total data set (TDS) and minimum data set (MDS) methods...

Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential

In this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in four carborane-derivatized oxindoles and a unique zwitterionic amidine featuring a nido-cluster. We tested the anti-cancer potential of these prodrugs against murine colon adenocarcinoma (MC38)...

Green Extraction of Bioactives from Curcuma longa Using Natural Deep Eutectic Solvents: Unlocking Antioxidative, Antimicrobial, Antidiabetic, and Skin Depigmentation Potentials

This study evaluates the efficiency of 20 Natural Deep Eutectic Solvents (NADES) formulations for extracting curcuminoids and other bioactive compounds from turmeric and emphasize their ability to preserve and enhance antioxidant, antimicrobial, antidiabetic, and skin depigmentation effects. The NADES formulations, prepared using choline chloride (ChCl) combined with sugars...

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